Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes

[摘要] References(15)Cited-By(6)Hot flushes are the most common complaint of menopausal women. In the present study, a new animal model of hot flushes was established. Tail skin temperature was measured with a thermo tracer after mice were subjected to a forced exercise task using a motor driven treadmill. In ovariectomized mice, forced exercise for 10 min was most effective in increasing tail skin temperature over that of sham-operated mice. This elevation was blocked by estradiol replacement (1 mg/kg per week for 3 weeks), suggesting that our model simulates menopausal hot flushes.

[学科分类] 药学

[关键词] ovariectomy;forced exercise;menopausal flushing