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Pathophysiological Significance of T-type Ca2+ Channels:Transcriptional Regulation of T-type Ca2+ Channel — Regulation of CACNA1H by Neuron-Restrictive Silencer Factor
[摘要] References(15)Cited-By(9)Expression of T-type Ca2+ current in the ventricle varies during development and in cardiac diseases. The alteration in quantity of two isoforms of T-type Ca2+ channel genes in the heart, CACNA1G and CACNA1H, contributes to the changes of T-type Ca2+ channel activity. However, the precise mechanisms governing the transcription of T-type Ca2+ channel genes remain largely unknown. In this review, we briefly describe our recent finding that a transcriptional repressor named neuron-restrictive silencer factor is a potent regulator of T-type Ca2+ channel gene expression.
[发布日期]  [发布机构] 
[效力级别]  [学科分类] 药学
[关键词] T-type Ca2+ channel;gene transcription;neuron-restrictive silencer factor;repressor [时效性] 
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