Methylmalonic Acidemia �? Cause of Recurrent Neonatal Death and Its Social Implications

[摘要] Mr and Mrs R, non-consanguineous couple had history of all their children during neonatal period. First two neonates were normal at birth, then presented with lethargy, vomiting and decreased acceptance of feeds. Both the babies expired after birth without being investigated for cause of death. The third neonate was investigated for inborn error of metabolism and found to be affected with methylmalonic acidemia. The couple departed away inspite of extensive counselling. In the fourth pregnancy antenatally fetus was diagnosed as carrier case of methylmalonic acidemia and short chain fatty acid oxidase deficiency. The fourth baby was normal and was in follow up till one year age.

[学科分类] 儿科学

[关键词] Methylmalonic Acidemia;recurrent neonatal death;social implications;SCAD deficiency