Intrarenal Distributions and Changes of Angiotensin-Converting Enzyme andAngiotensin-Converting Enzyme 2 in Feline and Canine Chronic KidneyDisease

[摘要] References(29)Cited-By(1)Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensinsystem (RAS). ACE2 is a newly identified member of the RAS. The presentimmunohistochemical study focused on changes in intrarenal ACE and ACE2 immunoreactivityin feline and canine chronic kidney disease (CKD). ACE immunoreactivity was predominantlyobserved in the brush border of the proximal tubules in dogs and cats. ACEimmunoreactivity was lower in CKD kidneys than in normal kidneys, and quantitativeanalysis demonstrated negative correlations between ACE and renal tissue damage in dogs.ACE2 immunoreactivity was also detected in the proximal tubules; it increased or decreasedwith CKD in dogs, depending on the renal region assessed. The changes in ACE and ACE2 inCKD were associated with the plasma creatinine concentration in dogs. Findings from dogswith glomerulonephritis were similar to those from dogs with non-glomerulonephritis. Thepresent study suggests that changes in the intrarenal expression of ACE and ACE2contribute to the pathological mechanisms of canine CKD, but not to the mechanisms offeline CKD.

[学科分类] 兽医学

[关键词] angiotensin-converting enzyme;angiotensin-converting enzyme 2;canine;chronic kidney disease;feline