Low-Level Laser Therapy Attenuates LPS-Induced Rats Mastitis by InhibitingPolymorphonuclear Neutrophil Adhesion

[摘要] References(35)Cited-By(1)The aim of this study was toinvestigate the effects of low-level laser therapy (LLLT) on a rat model oflipopolysaccharide (LPS)-induced mastitis and its underlying molecular mechanisms. The ratmodel of mastitis was induced by inoculation of LPS through the canals of the mammarygland. The results showed that LPS-induced secretion of IL-1β and IL-8 significantlydecreased after LLLT (650 nm, 2.5 mW, 30 mW/cm2). LLLT alsoinhibited intercellular adhesion molecule-1 (ICAM-1) expression and attenuated theLPS-induced decrease of the expression of CD62L and increase of the expression of CD11b.Moreover, LLLT also suppressed LPS-induced polymorphonuclear neutrophils (PMNs) enteringthe alveoli of the mammary gland. The number of PMNs in the mammary alveolus and themyeloperoxidase (MPO) activity were decreased after LLLT. These results suggested thatLLLT therapy is beneficial in decreasing the somatic cell count and improving milknutritional quality in cows with an intramammary infection.

[学科分类] 兽医学

[关键词] low-level laser therapy;mastitis;polymorphonuclear neutrophil;transmigration