The Effect of L-Carnitine on Oxidative Stress Responses of ExperimentalContrast-Induced Nephropathy in Rats

[摘要] References(55)Cited-By(5)This study was conducted to investigate the prophylactic effects of carnitineagainst contrast-induced nephropathy (CIN) and its relation to oxidant/antioxidant statusin kidney, liver, heart, spleen and lung tissues in a CIN rat model. Twenty-eight adultmale Wistar rats were divided into 4 groups, the control, contrast media (CM), carnitineand contrast media+carnitine (CM+carnitine) groups. Animals were placed in individualmetabolism cages, and on the 2nd day, rats were deprived of water for 24 hr. On the 3rdday, contrast media were administered to groups CM and CM+carnitine. L-carnitine wasadministered on days 2, 3 and 4. Histopathological changes were evaluated in the rightkidney after euthanization. Superoxide dismutase (SOD) and catalase (CAT) activities andglutathione (GSH) and malondialdehyde (MDA) levels were measured in renal, liver, heart,spleen and lung tissues. The SOD activities in the renal (P<0.05),liver (P<0.001) and spleen (P<0.05) tissues wereincreased in the carnitine group. The CAT activities in the spleen tissue were decreased(P<0.01) only in the CM group. Renal (P<0.05),liver (P<0.001), spleen (P<0.001) and lung tissue(P<0.01) GSH levels were found to be higher in the carnitine group.In renal, liver and lung tissues, the MDA levels increased in the CM group(P<0.001). The histopathological findings showed that L-carnitinemay have a preventative effect in alleviating the negative effects of CIN. Similar tothis, L-carnitine may play a major role in the stability of the antioxidant status in thekidney, liver, spleen and lung of the CIN rat model.

[学科分类] 兽医学

[关键词] antioxidant defense;contrast-induced nephropathy;L-carnitine;oxidative stress