Multicentric Histiocytosis Related to Avian Leukosis Virus Subgroup J(ALV-J)-Infection in Meat-Type Local Chickens

[摘要] References(13)Gross lesions characterized by swollen livers and spleens accompanied bydiffuse white miliary spots, which resembled those of Marek’s disease, were detected intwo flocks of local meat-type chickens at a Japanese poultry processing plant in June andAugust 2010. The microscopic examinations revealed proliferative foci consisting ofspindle or polymorphic cells in the interstitium of livers, splenic follicles and theinterstitium of kidneys. These cells were positive immunohistochemically with Iba1antibody, indicating they were histiocytic cells. Some of them contained antigens of avianleukosis virus (ALV) by immunohistochemistry,and the env gene of ALVsubgroup J was detected from the spleens by polymerase chain reaction (PCR). Phylogeneticanalysis of the PCR product indicated that the env gene might be descended from theAmerican ADOL-7501 strain of ALV-J. These results suggest that the swollen livers andspleens of the meat-type chickens may come from histiocytic proliferation caused by ALV-Jinfection.

[学科分类] 兽医学

[关键词] avian leukosis virus subgroup J (ALV-J);meat-type chicken;multicentrichistiocytosis