Sparing Effect of Robenacoxib on the Minimum Alveolar Concentration forBlunting Adrenergic Response (MAC-BAR) of Sevoflurane in Dogs

[摘要] References(25)Cited-By(1)Robenacoxib is a newer nonsteroidal anti-inflammatory drug approved for dogsand cats. This study was designed to evaluate the effect of robenacoxib on the minimumalveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs.Sevoflurane MAC-BAR was determined by judging dogs�? response to a noxious electricalstimulus (50 V, 50 Hz and 10 msec) for 10 sec in 6 beagle dogs on two occasions at least a7-day interval. In each occasion, saline (0.1 ml/kg) or robenacoxib (2mg/kg) was administered subcutaneously at 1 hr prior to the MAC-BAR determination.Robenacoxib significantly decreased the sevoflurane MAC-BAR (3.44 ± 0.53% for saline vs.2.84 ± 0.38% for robenacoxib, P=0.039). These results suggest thatsubcutaneous robenacoxib provides a clinically relevant sparing effect on anestheticrequirement.

[学科分类] 兽医学

[关键词] canine;MAC-BAR;robenacoxib;sevoflurane