Estimation of Glomerular Filtration Rate in Cynomolgus Monkeys(Macaca fascicularis)

[摘要] References(13)Cited-By(3)To estimate the glomerularfiltration rate (GFR) in cynomolgus monkeys (Macaca fascicularis), athree-blood-sample method using iodixanol was assessed in comparison with the conventionalmultisample strategy using inulin. Iodixanol and inulin were coadministered intravenously40 mg I/kg and 50 mg/kg, respectively, to male monkeys, followed by blood collection 60,90 and 120 min later. A close correlation (r=0.96) was noted between theGFR values estimated by both methods. In clinically healthy monkeys, the basal values weredetermined to be 3.06 ± 0.50 ml/min/kg. This is the first report,suggesting that serum clearance of iodixanol is a ready-to-use tool for a screening theGFR in monkeys, although it is necessary to perform a more longitudinal study usinganimals with reduced renal function.

[学科分类] 兽医学

[关键词] glomerular filtration rate;inulin;iodixanol;monkey;serum clearance