In Vitro Susceptibility ofMalassezia pachydermatis Isolates from Canine Skin withAtopic Dermatitis to Ketoconazole and Itraconazole in East Asia

[摘要] References(10)Cited-By(2)Topical or oral azole antifungals are commonly used in canine atopic dermatitis(AD), as the lipophilic yeast Malassezia pachydermatis exacerbates canineAD. To examine whether canine AD lesions harbor azole-resistant M.pachydermatis isolates in East Asia, we investigated the invitro susceptibility of M. pachydermatis isolates toketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesions of canines in Japan,Korea and Taiwan. The minimum inhibitory concentrations (MICs) of KTZ and ITZ weremeasured by the E-test using Sabouraud dextrose agar with 0.5% Tween 40. The MICs of KTZand ITZ for isolates from canines with AD were significantly higher than the MICs forisolates from healthy canines. Our findings suggested that the clinical isolates fromcanine AD skin lesions were less susceptible to azoles than those from normal canine skinin East Asia.

[学科分类] 兽医学

[关键词] azole;drug susceptibility;E-test;Malassezia pachydermatis