Trichoblastoma with Abundant Plump Stromal Cells in a Dog

[摘要] References(11)Histopathological and immunohistochemical examinations were made on a cutaneoustumor on the head of an 11-year-old female mixed-breed dog. The tumor was well demarcatedand comprised multilobular structures of neoplastic epithelial cells with abundant plumpperitumoral stromal cells. The neoplastic cells formed irregular cell cords or trabeculaeand were arranged in characteristic palisades at the periphery. Immunohistochemically,neoplastic cells were positive for p63 and the several cytokeratins examined. In contrast,the plump peritumoral stromal cells were positive for vimentin and unevenly for nestin, aneuroepithelial stem cell protein. The stromal cells prominently proliferated in proximityto epithelial neoplastic cells, suggesting a close interaction between these two celltypes.

[学科分类] 兽医学

[关键词] canine;nestin;stromal cell;trichoblastoma