Effects of Intermittent Positive Pressure Ventilation on CardiopulmonaryFunction in Horses Anesthetized with Total Intravenous Anesthesia Using Combination ofMedetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)

[摘要] References(27)Cited-By(2)Effects of intermittentpositive pressure ventilation (IPPV) on cardiopulmonary function were evaluated in horsesanesthetized with total intravenous anesthesia using constant rate infusions ofmedetomidine (3.5 µg/kg/hr), lidocaine (3 mg/kg/hr), butorphanol (24µg/kg/hr) and propofol (0.1 mg/kg/min) (MLBP-TIVA). Five horses wereanesthetized twice using MLBP-TIVA with or without IPPV at 4-week interval (crossoverstudy). In each occasion, the horses breathed 100% oxygen with spontaneous ventilation(SB-group, n=5) or with IPPV (CV-group, n=5), and changes in cardiopulmonary parameterswere observed for 120 min. In the SB-group, cardiovascular parameters were maintainedwithin acceptable ranges (heart rate: 33�?35 beats/min, cardiac output: 27�?30l/min, mean arterial blood pressure [MABP]: 114�?123 mmHg, meanpulmonary arterial pressure [MPAP]: 28�?29 mmHg and mean right atrial pressure [MRAP]:19�?21 mmHg), but severe hypercapnea and insufficient oxygenation were observed (arterialCO2 pressure [PaCO2]: 84�?103 mmHg and arterial O2pressure [PaO2]: 155�?172 mmHg). In the CV-group, normocapnea (PaCO2:42�?50 mmHg) and good oxygenation (PaO2: 395�?419 mmHg) were achieved by the IPPVwithout apparent cardiovascular depression (heart rate: 29�?31 beats/min, cardiac output:17�?21 l /min, MABP: 111�?123 mmHg, MPAP: 27�?30 mmHg and MRAP: 15�?16 mmHg).MLBP-TIVA preserved cardiovascular function even in horses artificially ventilated.

[学科分类] 兽医学

[关键词] cardiopulmonary function;horse;intermittent positive pressure ventilation (IPPV);MLBP-TIVA