Determination of the Prevalence of Helicobacterheilmannii-Like Organisms Type 2 (HHLO-2) Infection in Humans and DogsUsing Non-Invasive Genus/Species-Specific PCR in Korea

[摘要] References(19)Cited-By(5)Helicobacter spp. may have multiple routes of transmission. Itis unclear, however, whether the agent is zoonotic and therefore transmitted from ananimal reservoir, including dogs. The aim of this population-based study was to assess therelationship between pet ownership or frequent exposure to dogs andHelicobacter spp. infection, especially focusing on HHLO-2(Helicobacter heilmannii-like organisms type 2) in saliva and fecessamples in Korea, using non-invasive genus/species-specific PCR. One hundred twenty-foureligible human subjects and 39 dogs participated in this study. Relativity of contact withdogs and Helicobacter spp. infection diagnosed by genus-specific PCRshowed a statistically significant result (P<0.01), but in therelativity analyses between contact with dogs and H. pylori, H. felis andH. bizzozeronii infections diagnosed using species-specific PCR, onlyHelicobacter felis showed a statistically significant result. AlthoughH. pylori infection showed a statistically significant relativity, nostatistically significant association was found between veterinarian subjects andHelicobacter. spp., H. felis and H.bizzozeronii infections. On performing risk factor analyses of HHLO-2 infectionby transmission, using matching species, between HHLO-2-positive dog owners andHHLO-2-positive dogs, Helicobacter felis infection showed an extremelysignificant relativity (P<0.0001), and Helicobacterbizzozeronii may also be a possible significant risk factor(P<0.01). These results suggest that HHLO-2 infection might be azoonotic infection, because continuous contact with dogs was proved to be correlated withhuman H. felis and H. bizzozeronii infections in thisstudy.

[学科分类] 兽医学

[关键词] Helicobacter bizzozeronii;Helicobacter felis;Helicobacter pylori;HHLO-2 (Helicobacter heilmannii-like organisms type 2);PCR