Pathological and Immunohistochemical Findings of Natural Highly PathogenicAvian Influenza Infection in Tufted Ducks during 2010�?2011 Outbreaks inJapan

[摘要] References(19)Cited-By(1)In the winter of 2010�?2011, anoutbreak of highly pathogenic avian influenza virus (HPAIV) infection occurred in wild anddomestic birds in Japan. Tufted ducks were found dead in an urban area of Toyota City,Koriyama, Fukushima Prefecture. Two tufted ducks were examined histopathologically,immunohistochemically and molecularly. Gross findings included marked dark-red clottedblood in the pectoral muscles and multifocal hemorrhages on the serous membranes.Microscopically, non-suppurative meningoencephalitis, multifocal to coalescing pancreaticnecrosis and severe pulmonary congestion were observed. HPAIV antigen was detected in themalacic areas, neuronal, glial and ependymal cells, pulmonary capillary endothelial cellsand epithelium of pulmonary bronchioles, necrotic pancreatic acini and degenerated cardiacmyocytes. The HPAIV isolate was genetically classified into clade 2.3.2.1 group A. Thebroad distribution of virus antigen in brain and pulmonary tissues associated with HPAIVspontaneous infection in tufted ducks might be useful in understanding its pathogenesis innature.

[学科分类] 兽医学

[关键词] HPAIV;Japan;outbreak;tufted duck