The Relationship between Clinicopathological Features and Expression ofEpithelial and Mesenchymal Markers in Spontaneous Canine Mammary GlandTumors

[摘要] References(23)Cited-By(3)It is known that epithelialmesenchymal transition (EMT) contributes to the acquisition of malignant property in humancancers. However, the role of EMT in canine tumors remains to be elucidated. To evaluatethe correlation between expression levels of protein markers involved in EMT andclinicopathological characteristics in canine mammary gland tumors, immunohistochemistryusing antibodies against ZO-1, E-cadherin, vimentin, N-cadherin and fibronectin wasperformed on 119 clinical tissue samples. Consequently, loss of ZO-1 and E-cadherin, andgain of vimentin and N-cadherin were more frequently observed in malignant tumors than inbenign tumors. However, there was no correlation among expression of these molecules.Univariate and multivariate analysis identified that loss of E-cadherin independently hada low one-year survival rate (adjusted odds ratio: 2.3, P=0.02). Theseresults suggested that EMT might relate to acquisition of malignancy, and additionally,E-cadherin was strongly correlated with malignant behavior in canine mammary glandtumors.

[学科分类] 兽医学

[关键词] canine mammary gland tumors;epithelial mesenchymal transition;immunohistochemistry;prognosis