Notch2 Transduction by Feline Leukemia Virus ina Naturally Infected Cat

[摘要] References(30)Feline leukemia virus (FeLV)induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genesby FeLV is sometimes observed and associated with neoplastic diseases including lymphomaand sarcoma. Here, we report the first natural case of feline Notch2transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. Wecloned recombinant FeLVs harboring Notch2 in the envgene. Notch2 was able to activate expression of a reporter gene, similarto what was previously reported in cats with experimental FeLV-induced thymic lymphoma.Our findings suggest that the transduction of Notch2 strongly correlateswith FeLV-induced lymphoma.

[学科分类] 兽医学

[关键词] feline leukemia virus;hypercalcemia;lymphoma;Notch2;transduction