Systemic Oxygen Delivery and Consumption in Dogs with Heartworm Disease

[摘要] References(16)Cited-By(3)To investigate systemic oxygen (O2) transport, we calculated the oxygen delivery index (Do2I), oxygen consumption index (Vo2I) and oxygen extraction ratio (ER) in dogs with heartworm (HW) disease. The Do2I was 770±331 ml/min/kg in dogs mildly affected with pulmonary HW disease Showing respiratory signs, mild anemia and mild cardiac insufficiency (n=34); 238±155 ml/min/kg in dogs with ascitic pulmonary HW disease (n=7); and 577±320 ml/min/kg and 333±263 ml/min/kg in dogs with caval syndrome (CS) which survived (n=15) or died (n=7) after surgical HW removal. The Do2I was lower (P < 0.01) in all HW-infected groups, especially in ascites and CS-non-surviving dogs, than in HW-free dogs (n=11, 1041±264 ml/min/kg). The Vo2I was higher in some mildly affected dogs (161±88 ml/min/kg), and lower (P < 0.01) in ascitic dogs (45±53 ml/min/kg) than in HW-free dogs (123±44 ml/min/kg). The ER was higher (P < 0.01) in all HW-infected groups than in HW-free dogs. The Do2I correlated significantly with Vo2I (r=0.84, P < 0.01), and the Vo2I correlated significantly with ER (r=0.48, P < 0.01). The Do2I correlated significantly with arterial O2 tension (r=0.33), serum LDH (r=-0.46) and CK (r=-0.46) activities, serum urea nitrogen (UN, r=-0.32) and lactic acid (LA, r=-0.39) concentrations and cardiac index (r=0.64). The Vo2I correlated significantly with serum LDH (-0.43) and CK (r=-0.41) activities, serum UN (r=-0.29) and LA (r=-0.37) concentrations, cardiac index (r=0.53) and body weight (r=-0.34). The ER correlated significantly with mixed venous O2 tension (r=-0.38) and serum ALT activity (r=0.31). The delivery and consumption of O2 may be closely associated with organ injury in dogs with HW disease.

[学科分类] 兽医学

[关键词] canine;extraction rate;heartworm disease;oxygen consumption;oxygen delivery