Acute Changes in Central Corneal Thickness According to ExperimentalAdjustment of Intraocular Pressure in Normal Canine Eyes

[摘要] References(25)Cited-By(1)Central corneal thickness (CCT) can be a promising source of glaucoma monitoring anddiagnosis. This study evaluated changes in CCT according to experimental adjustment ofintraocular pressure (IOP) in canine eyes. To adjust and measure IOP, each eye wascannulated with two 26-gauge needles under inhalant anesthesia. One needle was connectedto a pressure transducer, and the other was connected to an adjustable bag of physiologicsaline. IOP was stepwise increased from 10 mmHg to 70 mmHg in 10 mmHg increments (GroupT). IOP was maintained at 15 mmHg (Group C15), 30 mmHg (Group C30), 45 mmHg (Group C45),60 mmHg (Group C60) and 75 mmHg (Group C75) during the experiment. CCT was measured withan ultrasonic pachymeter every 10 min after cannulation. There was a significantdifference in the effect of time on CCT (P<0.001) and difference inCCT (dCCT; P<0.001) between groups. The CCT of group C15 remainedconstant during the experiment. However, group T showed an initial decrease and then anincrease after passing the lowest point. Group C30 showed decreasing values for 30 min,after which the values remained constant. The values in Group C45 showed no changes for 40min and then increased. The values in group C60 showed no change for 20 min and thenincreased. Group C75 showed a steady increase. In conclusion, the CCT showed two corechanges according to increased IOP. This study provides essential basic data to enablefurther investigation into the association of IOP and CCT in dogs.

[学科分类] 兽医学

[关键词] canine;central corneal thickness;glaucoma;intraocular pressure;pachymeter