Context-sensitive half-time of fentanyl in dogs

[摘要] References(14)Context-sensitive half-times (CSHTs) of fentanyl in dogs were determined usingpharmacokinetic models reported by Murphy et al. and Sano etal., and compared with a human model. The CSHT was defined as the time requiredfor a 50% decrease in drug concentration in the central compartment after the terminationof infusion. Although CSHTs increased gradually as the infusion time increased, the CSHTsin dogs were shorter than those in humans. The CSHTs at steady-state were 31.3 and 69.2min in dogs, and 306.5 min in humans. The CSHTs of fentanyl in dogs are apparently shorterthan those in humans; therefore, a continuous infusion of fentanyl may be a rationalregimen in dogs, even if duration of infusion is extended.

[学科分类] 兽医学

[关键词] canine;fentanyl;half-time;infusion;pharmacokinetics