Efficacy and safety of lomefloxacin on bacterial extraocular disease in thehorse

[摘要] References(27)Lomefloxacin is a broad-spectrum fluoroquinolone antibiotic used for the treatment ofbacterial extraocular disease. This study investigated the efficacy and safety oflomefloxacin eye drops for bacterial extraocular disease in horses. Lomefloxacinophthalmic solution (0.3%) was instilled three times daily for 2�?5 days in 65 horsesdiagnosed with bacterial extraocular disease based on clinical findings. Clinicalobservations and bacteriological examinations were performed at the start of treatment, 2and 5 days after the start of treatment, and at the discontinuation or termination oftreatment. Of the 65 horses, 64 were positive for bacteria, and 22 bacterial genera and 47bacterial species were identified. The efficacy of lomefloxacin was evaluated in 63horses; one horse with a negative culture and another with suspected bacterialcontamination were excluded. Lomefloxacin was considered to be clinically effective in 54horses. The major bacterial species identified were Staphylococcusaureus, Streptococcus equi subsp. zooepidemicus,Acinetobacter lwoffii, Staphylococcus xylosus,Staphylococcus vitulinus, Enterobacter agglomerans,Flavimonas oryzihabitans and Staphylococcus sciuri,with a cumulative disappearance rate of 80% or more at the termination of instillation.Excluding one horse that did not undergo a bacteriological examination, the remaining 62horses were assessed for bacteriological outcome. Full or partial bacterial clearance wasdetected in 95% or more of the 62 horses. One of the 65 horses reported adverse eventsthat had no causal relation with the eye drops. Our results showed that lomefloxacin issafe and effective for the treatment of bacterial extraocular disease in horses.

[学科分类] 兽医学

[关键词] bacterial culture;bacterial extraocular disease;clinical study;equine;lomefloxacin