Evaluation of membrane filtration system using The “Pore Diffusion�? foreliminating viruses

[摘要] References(12)Here, we report a first study of virus removal by a novel membrane filtration system,named the “Pore Diffusion�?. The “Pore Diffusion�? manipulated the direction of circulatingflow from vertical to parallel to the membrane, thereby achieved to alter thetrans-membrane pressure as low as possible. We compared the viral activity between beforeand after filtration by both infectivity assay and real-time reverse transcription-PCR.Among 4 “Pore Diffusion�? modules tested, the big module with average pore size of 80 nmshowed the highest log reduction value of viral activity. Our study shows the possibilityof “The Pore Diffusion�? to filtrate viruses from bioproducts without increasing thetrans-membrane pressure, so that the filtration process can be carried out effectively andeconomically.

[学科分类] 兽医学

[关键词] brownian motion;laminar flow;The Pore Diffusion;trans-membrane pressure;turbulence flow