Adjuvanticity and Inflammatory Response Following Administration of Water-in-Oil Emulsions Prepared with Saturated Hydrocarbons in Chickens

[摘要] References(9)Cited-By(3)Water-in-oil emulsions containing bovine serum albumin (BSA) as a model antigen were prepared using aliphatic saturated hydrocarbons with carbon number from 12 to 18, and were tested in chickens. Straight-chain hydrocarbons induced higher antibody titers against BSA after administration than branched-chain hydrocarbons. n-C 16H34 and n-C18H38 maintained high antibody titers even at 32 weeks after administration, compared with n-C12H26, n-C14H30 and n-C15H32. n-C12H26 and n-C14H30 raised concentrations of sialic acid and creatine kinase in plasma, both of which are important markers of inflammatory responses, immediately after administration. n-C 16H34 and n-C18H38 did not raise the values of these markers. These results indicated that n-C16H34 and n-C18H 38 induced elevated and sustained immune responses without severe adverse reactions in chickens.

[学科分类] 兽医学

[关键词] adjuvanticity;hydrocarbon;inflammation