Effect of Recombinant Human Granulocyte Colony Stimulating Factor on Lymphocyte Blastogenesis in Healthy Dogs

[摘要] References(17)Cited-By(1)Effects of recombinant human granulocyte colony−stimulating factor(rhG−CSF)on the number and blastogenesis of lymphocytes were evaluated in clinically healthy dogs treated subcutaneously with rhG−CSF at a dose of 2.5 μg/kg for 3 days.Significant increases in the number of leukocytes and segmented neutrophils were observed after the administration of rhG−CSF.The number of lymphocytes also increased on days 1 and 2 after the treatment.Activities of phytohemagglutinin, concanavalin A, and pokeweed mitogen−induced lymphocyte blastogenesis(LB)were augmented to twice the pretreatment levels by the administration of rhG−CSF.These results suggested that administration of rhG−CSF activated lymphocyte functions such as LB in healthy dogs.

[学科分类] 兽医学

[关键词] canine;lymphocyte blastogenesis;recombinant human granulocyte colony-stimulating factor