Immunohistochemical Observations of Macrophages and Perisinusoidal Cells in Carbon Tetrachloride-induced Rat Liver Injury

[摘要] References(20)Cited-By(13)In rat liver injured by carbon tetrachloride, ED-1-positive monocytes and resident macrophages significantly increased in number in damaged perivenular zones on days 2 and 4 after single or double dosing, peaking on day 2 and being two-fold more after the 2nd dosing. ED-2-positive resident macrophages significantly increased in number only on day 4 after the single dosing and on days 2, 4 and 6 after the 2nd dosing with a peak on day 2. A significant increase in number of muscle actin-positive perisinusoidal cells was seen on day 4 and on days 2 and 4 after the 1st and 2nd dosings, respectively, reaching a peak on day 4 and being more remarkable after the 2nd dosing.

[学科分类] 兽医学

[关键词] CCl4;immunohistochemistry;liver injury;macrophage;perisinusoidal cell