Comparison of the effects of long-term pimobendan and benazepriladministration in normal cats

[摘要] References(22)Pimobendan (PIMO) can cause adverse effects, such as mitral valve degeneration, in dogs;however, it is unclear whether these effects occur in cats. Therefore, we aimed todetermine whether PIMO or benazepril produces adverse cardiac effects in healthy cats.This was a blinded, randomized, prospective parallel study. Twelve cats were randomlydivided into two groups of six cats, namely, an angiotensin-converting-enzyme inhibitorgroup that received benazepril and a PIMO group. Cats were administered their respectivetreatments for 506 days, and we evaluated cardiac parameters, blood biochemistry andglomerular filtration rates during that time. At the end of the trial, the cats wereeuthanized, and histopathological examinations were performed by a pathologist who wasblinded to the treatment groups. No significant changes were observed in any of theparameters measured in either of the groups. In particular, no significant cardiac lesionswere observed in either of the groups. In healthy cats, neither PIMO nor benazeprilappears to cause cardiac lesions, but future studies are needed to examine the effects ofPIMO in cats with heart disease.

[学科分类] 兽医学

[关键词] angiotensin-converting-enzyme inhibitor;healthy cat;mitral valve;pimobendan