Poorly differentiated salivary gland carcinoma with prominent squamousmetaplasia in a pregnant Wistar Hannover rat

[摘要] References(17)A subcutaneous pale brown-colored mass was observed macroscopically in the ventral neckof a 16-week-old Wistar rat on day 18 of gestation. The mass was well demarcated from theadjacent tissues with partial invasion into connective tissues. Necrosis and hemorrhagewere evident throughout the mass. The mass comprised a diffuse sheet and a nest-likestructure of epithelial cells with prominent squamous metaplasia. The neoplastic cellstested immunopositive for keratin, vimentin, glial fibrillary acidic protein and p63. Aportion of the neoplastic cells exhibited a similar immunoreaction of prominin-1 to theductal and acinar cells in normal submandibular and parotid glands. Collectively, thetumor was diagnosed as a poorly differentiated carcinoma derived fromepithelial/myoepithelial lineages in the submandibular and/or parotid glands.

[学科分类] 兽医学

[关键词] carcinoma;immunohistochemistry;rat;salivary gland