Coexistence of two forms of disease-associated prion protein in extracerebraltissues of cattle infected with H-type bovine spongiform encephalopathy

[摘要] References(25)H-type bovine spongiform encephalopathy (H-BSE) is an atypical form of BSE in agedcattle. H-BSE is characterized by the presence of two proteinase K-resistant forms ofdisease-associated prion protein (PrPSc), identified as PrPSc #1 andPrPSc #2, in the brain. To investigate the coexistence of differentPrPSc forms in the extracerebral tissues of cattle experimentally infectedwith H-BSE, immunohistochemical and molecular analyses were performed by usingN-terminal-, core-region- and C-terminal-specific anti-prion protein antibodies. Ourresults demonstrated that two distinct forms of PrPSc coexisted in the variousextracerebral tissues.

[学科分类] 兽医学

[关键词] atypical BSE;extracerebral tissue;H-type;peripheral nervous system;prion