Age-dependency of the serum oxidative level in the senescence-acceleratedmouse prone 8

[摘要] References(20)Systemic oxidative stress is considered to cause aging. In this study, to estimate theoxidative stress level in senescence-accelerated mouse prone 8 (SAMP8), we evaluated serumreactive oxygen species production and reduction capacity by measurement ofDiacron-Reactive Oxygen Metabolites (d-ROM) and Biological Antioxidant Potential (BAP),respectively, with age. SAMP8 showed earlier increase of d-ROM value with age than SAMresistant 1 (SAMR1), the control strain. The BAP level was the highest in adult SAMP8,whereas SAMR1 presented the sustained BAP values between ages. These results indicate thatoxidative stress in SAMP8 is higher than SAMR1. Our study is the first detailed reportabout d-ROM and BAP in SAMP8 and will provide useful fundamental data for future agingstudies.

[学科分类] 兽医学

[关键词] aging;BAP;d-ROM;oxidative stress;senescence-accelerated mouse