Iridociliary adenocarcinoma with oncocytic change in a dog

[摘要] References(20)An intraocular mass lesion was found in the left eyeball in a spayed female PembrokeWelsh Corgi dog. The surgically resected left eyeball was pathologically examined.Histologically, the mass lesion consisted of proliferation of the atypical cuboidal orcolumnar epithelial cells, arranging in papillary, tubular or solid form. In addition,some neoplastic cells showed oncocytic change characterized as large oval cells withnumerous eosinophilic intracytoplasmic granules. Cytoplasm of the oncocytic cells showeddark blue granules by phosphotungstic acid-hematoxylin stain. Immunohistochemically, theoncocytic cells were intensely positive for cytochrome C. Based on these findings, theocular mass was diagnosed as iridociliary adenocarcinoma with oncocytic change. Thefindings indicate that the oncocytic changes of the neoplastic epithelial cells might becaused by mitochondrial accumulation.

[学科分类] 兽医学

[关键词] canine;iridociliary adenocarcinoma;oncocytic change