Canine pyometra: a model for the analysis of serum CXCL8 ininflammation

[摘要] References(31)Cited-By(1)Interleukin-8 (IL-8 or CXCL8) is a highly selective pro-inflammatory chemokine,that is elevated in sera of humans and animals with various inflammatory diseases. CXCL8is possibly involved in uncontrolled inflammation and the development of a systemicinflammatory response syndrome (SIRS) and sepsis. Nevertheless, its behavior and preciseproperties in the course of inflammation are not fully understood. Thus, we used naturallyoccurring canine pyometra as a model of inflammation, in order to examine the behavior ofserum CXCL8 in relation to the disease intensity and commonly analyzed inflammatorymediators. Using a commercially available canine ELISA kit, a significant increase ofCXCL8 was determined in the serum of 23 dogs with pyometra compared with 35 healthy dogs.Interestingly, serum CXCL8 did not increase in severely diseased patients and behavedcontrary to white blood cells (WBC), neutrophils and C-reactive protein (CRP). Themeasurement of serum CXCL8 may provide valuable information about the extent of ongoinglesions and could be a useful complement for existing laboratory tests.

[学科分类] 兽医学

[关键词] canine;CXCL8;inflammation;pyometra;serum