The effect of 1 year of trilostane treatment on peripheral lymphocyte subsetsin dogs with pituitary-dependent hyperadrenocorticism

[摘要] References(22)This study investigated the changes in lymphocyte subsets during the trilostanemedication of Pituitary-dependent hyperadrenocorticism (PDH) dogs. The cortisol level andlymphocyte subsets of eight dogs with PDH were monitored 0, 1, 3, 6, 9 and 12 months afterthe initiation of trilostane treatment. White blood cells (WBC), lymphocytes,CD3+ (T lymphocyte), CD4+ (helper T lymphocyte), CD8+(cytotoxic T lymphocyte) and CD21+ (B lymphocyte) cells were measured. Althoughthe post-ACTH stimulation test cortisol level was significantly lower during trilostanetreatment, changes in the CD3+, CD4+, CD8+ andCD21+ counts were not observed. Meanwhile, significant decrease was observedin WBC counts during trilostane treatment. These indicate that long-term trilostanetreatment has little effect on the lymphocyte subsets in PDH dogs.

[学科分类] 兽医学

[关键词] ACTH stimulation test;cortisol;immune suppression;white blood cells