Vaginal clear cell carcinoma in a Japanese Black cow

[摘要] References(14)During artificial insemination of an 18-year-old female Japanese Black cow, a mass thatwas of a hen’s egg size was found in the vagina. On necropsy, the firm mass, measuringapproximately 3.5 × 3.5 × 3.0 cm, was located at the superior region of the vagina. Thecut surface of the mass was gray-white in color with occasional necrotic or hemorrhagicareas. Histologically, the mass was composed of tumor cells arranged in solid nests ofvarious sizes with an occasional tubular structure separated by a delicate fibrovascularstroma. The tumor cells had a hypochromatic nucleus and abundant, faintly eosinophiliccytoplasm. The tumor cells contained diastase-sensitive periodic acid-Schiff positivegranules. Immunohistochemically, tumor cells were positive for cytokeratin AE1/AE3, CAM5.2and carcinoembryonic antigen, but not for vimentin, p63, estrogen receptor-α, progesteronereceptor, α-smooth muscle actin, neuron-specific enolase, S-100 protein and chromograninA. On the basis of these findings, the tumor was diagnosed as a clear cell carcinoma ofthe vagina.

[学科分类] 兽医学

[关键词] clear cell carcinoma;Japanese Black cow;tumor;vagina