A new insertion/deletion fragment polymorphism of inhibin-α gene associatedwith follicular cysts in Large White sows

[摘要] References(21)Ovarian follicular cysts are anovulatory follicular structures that lead to infertility.Hormones play key roles in the formation and persistence of cysts. Inhibins areheterodimeric gonadal glycoprotein hormones that belong to the transforming growthfactor-β superfamily. These hormones suppress the secretion of follicle-stimulatinghormone. In this report, partial fragment of inhibin-α (INHA) subunit gene of Large Whitepig was detected from the genomic DNA by polymerase chain reaction. The sequence showed a283 bp fragment insertion/deletion (I/D) polymorphism in INHA subunit gene. A total of 49Large White sows with cystic follicles and 152 normal sows were screened for thispolymorphism. The relationship of INHA I/D polymorphisms with follicular cysts wasinvestigated. The distribution of I/D was significantly different between cystic andnormal sows, thereby suggesting that the INHA subunit gene might be a potential biologicalmarker for breeding programs in pig.

[学科分类] 兽医学

[关键词] follicular cyst;inhibin α;polymorphism;swine