Subtelomeric Chromosome Rearrangements in Children with Idiopathic Mental Retardation: Applicability of Three Molecular-cytogenetic Methods

[摘要] Aim To identify cryptic subtelomeric rearrangement, a possible cause of idiopathic mental retardation by means of multiprobe telomere fluorescent in situ hybridization (T-FISH). Methods Hundred patients (median age 3.0 years) with mental...

[学科分类] 卫生学

[关键词] subtelomeric rearrangements;subtelomeric fluorescent in situ hybridization (FISH);multiplex ligation-dependent probe amplification...