Nesfatin-1: An Overview and Future Clinical Application

[摘要] References(23)Cited-By(34)Nesfatin/nucleobindin2 (NUCB2) is expressed in the appetite-control hypothalamic nuclei andbrainstem nuclei. Nesfatin/NUCB2 expression in the paraventricular nucleus ofthe hypothalamus was modulated by starvation and refeeding.Intracerebroventricular administration of nesfatin-1 dose-dependently inhibitedfood intake for 6 hours in male Wistar and leptin resistant, Zucker fatty rats.Intraperitoneal administration of nesfatin-1 and its mid-segment (M30)dosedependentlyinhibited food intake for 3 hours in male ICR mice.Intraperitoneal administration of M30 also decreased foodintake inleptin-resistant, genetically obese (ob/ob), diabetic (db/db) mice and mice fed a 45% high fat dietfor 28 days. Intraperitoneal administration of M30 increased proopiomelanocortinand cocaine- and amphetamine- related peptide mRNA expression in the nucleus ofthe solitary tract of mice. In addition, intranasal administration ofnesfatin-1 significantly inhibited food intake for 6 hours in male Wistar rats.We summarize recent observations about nesfatin-1, and attempt to present futuredirection of nesfatin-1 research for developing a new anti-obesity treatment.

[学科分类] 内分泌与代谢学

[关键词] Nesfatin-1;Leptin;Food intake;Body weight;Obesity