The KATP Channel and Neonatal Diabetes

[摘要] References(63)Cited-By(8)ATP-sensitive potassium (KATP) channels play a key role in glucose-dependent insulin secretion in pancreatic β-cells. Recently, activating mutations in β-cell KATP channels were found to be an important cause of neonatal diabetes. In some patients, these mutations may also affect KATP channel function in muscles, nerves and brain which can result in a severe disease termed DEND syndrome (Developmental delay, Epilepsy and Neonatal Diabetes). This review focuses on mutations in the pore-forming KATP channel subunit (Kir6.2) that cause neonatal diabetes and discusses recent advances in our understanding of clinical features of neonatal diabetes, its underlying molecular mechanisms and their impact on treatment.

[学科分类] 内分泌与代谢学

[关键词] Neonatal diabetes;KATP channel