Predictive impact of adiponectin for detecting dysglycemia in non-fasting Japanese employees with metabolic risk factors

[摘要] References(33)The screening of dysglycemia in the non-fasting state is a challenging issue in healthcare practice.We investigated whether the additional measurement of circulating adiponectin levels could improve screening performance.We used a database of 1190 Japanese employees with metabolic risk factors, who underwent a 75-g oral glucose tolerance test (OGTT), following non-fasting health check-ups.Dysglycemia was defined as fasting glucose levels ≥6.1 mmol/L or 2-hr glucose levels ≥7.8 mmol/L during the OGTT.Logistic regression analysis revealed that decreased adiponectin levels were associated with dysglycemia, independently of postprandial glucose (PG) and hemoglobin A1c (HbA1c) levels, as well as other health check-up data (p<0.01).The trivariate model with PG, HbA1c, and adiponectin levels (PG+A1c+ADN model) had a larger area under the receiver operating characteristic curves (AUC) than the bivariate model with only PG and HbA1c levels (0.746 vs. 0.729; p=0.01).However, the AUC of the multivariate model with PG, HbA1c, and other health check-up data, but not adiponectin levels (PG+A1c+Other model) was 0.815, much larger than that of the PG+A1c+ADN model (p<0.01).The addition of adiponectin levels to the PG+A1c+Other model had a significantly larger AUC than the A1c+PG+Other model only in the subgroup without abdominal obesity (p=0.01), but not in the overall population (p=0.06) or in the subgroup with abdominal obesity (p=0.62).In conclusion, circulating adiponectin levels were independently associated with dysglycemia in non-fasting Japanese employees with metabolic risk factors, but they improved the screening capacity only in those without abdominal obesity.

[学科分类] 内分泌与代谢学

[关键词] Dysglycemia;Screening performance;Non-fasting state;Adiponectin