Rebound Hypersecretion of GH Following Octreotide Withdrawal due to Liver Dysfunction in an Acromegalic Patient

[摘要] References(13)Cited-By(1)Octreotide usually induces long-acting inhibition of GH secretion without rebound hypersecretion. We report a patient with acromegaly who showed rebound elevation of GH and insulin-like growth factor-1(IGF-1) after octreotide withdrawal. The patient responded remarkably to octreotide therapy with normalization of GH and IGF-1 and shrinkage of pituitary macroadenoma. Octreotide therapy was stopped when he developed liver dysfunction. GH and IGF-1 were markedly elevated for two weeks after cessation of octreotide.

[学科分类] 内分泌与代谢学

[关键词] Acromegaly;Octreotide;Rebound hypersecretion;Liver injury