Octreotide Improved Ventricular Arrhythmia in an Acromegalic Patient

[摘要] References(6)Cited-By(2)We saw a remarkable effect of octreotide, the long-acting somatostatin analogue, in reducing the number of ventricular premature complexes (VPCs) in a 59-year-old woman with acromegaly. Her basal GH and IGF-1 levels were up to 22.9ng/ml and 934.9ng/ml respectively. MRI revealed a 14×12×10mm mass lesion in the pituitary gland. She had hypertension and echocardiography showed an increase in left ventricular wall thickness. Electric cardiography showed the presence of frequent VPCs and 24-h Holter monitoring revealed 24277 beats of multifocal VPCs/24h. She was treated with 300μg/day of octreotide for four weeks before transsphenoidal surgery. After octreotide treatment, GH and IGF-1 were suppressed to 1.8ng/ml and 145.3ng/ml respectively, and the tumor size was remarkably reduced. Furthermore, the number of VPCs was also dramatically reduced to 2062 VPCs/24-h (8.5% of pretreatment) with 24-h Holter monitoring. This case shows that VPCs of acromegalic patients can be controlled by suppressing GH and IGF-lwith octreotide, and this agent is useful for reducing both tumor size and frequency of VPCs prior to surgery.

[学科分类] 内分泌与代谢学

[关键词] Acromegaly;Octreotide;Ventricular arrhythmia;Acromegalic cardiomyopathy