A Patient of Short Stature with Normal GH Secretion, but a Low Serum IGF-I Level

[摘要] References(5)We report the case of a 7-year-old patient of short stature who had normal GH secretion, but a very low serum IGF-I level. On admittance, his height and weight were 102.2cm (-3.8S.D.) and 15.7kg (-1.8S.D)., respectively. His bone age was 2 years and 8 months. The serum GH responses to insulin, glucagon and L-dopa were all normal. GH secretion during sleep was also normal, but the serum IGF-I level was very low (29ng/ml). The serum IGF-I level was greatly increased by the administration of GH. No mutation was detected in the GH-1 gene. His height velocity was noticeably improved by GH treatment.

[学科分类] 内分泌与代谢学

[关键词] Short Stature;Normal GH secretion;Low serum IGF-I;GH-1 gene;GH therapy