A Case of Renin-Producing Adrenocortical Cancer

[摘要] References(14)Cited-By(3)Here we report a case of a renin-producing adrenocortical carcinoma. A 57-year-old woman was referred to our hospital complaining of thirst and generalized muscle weakness. She was diagnosed as being hypertensive and diabetic with associated hypokalemia and she had a hard elastic mass with a diameter of 10cm on the left side of her neck. An abdominal computed tomography scan revealed a suprarenal mass on the left side (8.5×8×6.5cm). Endocrinological examination demonstrated a marked elevation in the patient's serum glucocorticoid and sex steroid hormones as well as plasma renin activity. Histological examination of a sample taken from the neck mass revealed a metastasis from an adrenal carcinoma, which was stained positively with antibodies against cytochrome P450 and renin, establishing the diagnosis of a renin-producing adrenocortical carcinoma. Trilostane was effective in reducing serum cortisol levels, but mitotane was ineffective.

[学科分类] 内分泌与代谢学

[关键词] Adrenal carcinoma;Renin-producing tumor;Hypertension;Hypokalemia;Trilostane;Mitotane