Dysregulation of glucose metabolism even in Chinese PCOS women with normal glucose tolerance

[摘要] References(23)Cited-By(4)To clarify the necessity of improving glucose metabolism in polycystic ovary syndrome (PCOS)women as early as possible, 111 PCOS women with normal glucose tolerance and 92 healthy age-matched controls were recruited to investigate glucose levels distribution, insulin sensitivity and β cell function.91 PCOS women and 33 controls underwent hyperinsulinemic-euglycemic clamp to assess their insulin sensitivity, which was expressed as M value. β cell function was estimated by homeostatic model assessment (HOMA)-β index after adjusting insulin sensitivity (HOMA-βad index).Compared with lean controls, lean PCOS women had similar fasting plasma glucose (FPG), higher postprandial plasma glucose (PPG) (6.03±1.05 vs. 5.44±0.97 mmol/L, Pvs. 4.90±0.39, Pvs. 5.44±0.97 mmol/L, P2.In conclusion, insulin resistance and dysregulation of glucose metabolism were common in Chinese PCOS women with normal glucose tolerance.BMI ≥ 25.545kg/m2 indicated impaired β cell function in PCOS women with normal glucose tolerance.

[学科分类] 内分泌与代谢学

[关键词] Polycystic ovary syndrome;β cell function;Insulin resistance;Normal glucose tolerance