Association between thyroid stimulating hormone receptor gene intron polymorphisms and autoimmune thyroid disease in a Chinese Han population

[摘要] References(32)Cited-By(12)Autoimmune thyroid disease (AITD) is a multifactorial disease with a genetic susceptibility and environmental factors.The thyroid stimulating hormone receptor gene (TSHR) which is expressed on the surface of the thyroid epithelial cell is thought to be the main auto-antigen and a significant candidate for genetic susceptibility to AITD.This case-control study aimed at evaluating the association between single nucleotide polymorphisms (SNP) of TSHR and AITD in a Chinese Han population.We recruited 404 patients with Graves’ disease (GD), 230 patients with Hashimoto’s thyroiditis (HT) and 242 healthy controls.The Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform was used to detect five SNPs (rs179247, rs12101255, rs2268475, rs1990595, and rs3783938) in TSHR gene.The frequencies of allele T and TT genotype of rs12101255 in GD patients were significantly increased compared with those of the controls (P=0.004/0.015, OR=1.408/1.446).The allele A frequency of rs3783938 was greater in HT patients than in the controls (P=0.025, OR=1.427).The AT haplotype (rs179247-rs12101255) was associated with an increased risk of GD (P=0.010, OR=1.368).The allele A of rs179247 was associated with ophthalmopathy in GD patients.These data suggest that the polymorphisms of rs12101255 and rs3783938 are associated with GD and HT, respectively.

[学科分类] 内分泌与代谢学

[关键词] Thyroid stimulating hormone receptor (TSHR);Single nucleotide polymorphism (SNP);Autoimmune thyroid disease (AITD);Graves’ disease (GD);Hashimoto’s thyroiditis (HT)