Clinical and endocrinological characteristics of adrenal incidentaloma in Osaka region, Japan

[摘要] References(24)The aim of this study was to investigate the clinical and endocrinological characteristics of adrenal incidentalomas in Osaka region, Japan.The study was a multicenter retrospective analysis of 150 patients with adrenal incidentalomas who underwent radiographic and endocrine evaluations between 2005 and 2013.Most adrenal incidentalomas were discovered by computed tomography (77.0%) and the rest were identified by abdominal ultrasonography (14.6%), magnetic resonance imaging (4.2%), or positron emission tomography (4.2%).Adrenal incidentalomas were more frequently localized on the left side than on the right.The average diameter of tumors was 21 ± 11 mm.On endocrinological evaluation, 14 patients were diagnosed with primary aldosteronism (9.3%), 10 with subclinical Cushing’s syndrome (6.7%), 7 with pheochromocytoma (4.7%), 7 with Cushing’s syndrome (4.7%), 2 with both subclinical Cushing’s syndrome and primary aldosteronism (1.3%), and 110 with non-functioning tumors (73.3%).Patients with functioning tumors were significantly younger and had larger tumor diameters than those with non-functioning tumors.Except for hypertension, complications were comparable between patients with functioning and non-functioning tumors, including the presence of glucose intolerance, cardiovascular disease, and dyslipidemia.In conclusion, a higher prevalence of primary aldosteronism was observed compared with a previous report.Complications were comparable between patients with functioning and non-functioning tumors, including the frequencies of glucose intolerance, cardiovascular disease, and dyslipidemia.Long-term follow-up is required in patients with non-functioning tumors because the frequency of complications, such as glucose intolerance, cardiovascular disease, and dyslipidemia, was equal to that in patients with functioning tumors.

[学科分类] 内分泌与代谢学

[关键词] Adrenal incidentaloma;Cushing’s syndrome;Pheochromocytoma;Primary aldosteronism;Non-functioning tumors