Production of 8-OHdG and Cytochrome c by Cultured Human Mononuclear Cells in Patients with Autoimmune Thyroid Disease

[摘要] References(19)Cited-By(4)Since oxidative stress is related to autoimmune thyroid disease, we studied the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cytochrome c by culture of mononuclear cells from patients with Graves' disease and Hashimoto's thyroiditis. In patients with untreated Graves' disease, 8-OHdG and cytochrome c levels in culture supernatant of mononuclear cells were significantly higher than those of healthy control subjects, while the Cytochrome c levels were significantly higher in patients with untreated Graves' disease and Hashimoto's thyroiditis than those of control subjects. Significant correlations between 8-OHdG and FT4i and cytochrome c were found. These results indicated that thyroid function has a potent influence on oxidative stress.

[学科分类] 内分泌与代谢学

[关键词] 8-OHdG;Cytochrome c;Autoimmune thyroid disease