The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance

[摘要] ENGLISH ABSTRACT:Infertility is a very common problem worldwide. Recent data have shown that disorders of themale represent the most common single defined cause of infertility. This proposal examinesthe clinical significance and fundamental physiological aspects of human gamete interaction.These studies are focused on the assessment of the cellular-molecular mechanisms involved inhuman sperm binding to its homologous zona pellucida resulting in the physiologic inductionof the acrosome reaction. We have developed and validated in vitro bioassays that assessspecific steps of the fertilization process that are critical for early embryo development. Theresults of our translational research have already had a significant impact on the overallevaluation of male infertility and on the clinical management of the infertile man in theassisted reproduction arena. Furthermore, the unveiling of the basic mechanisms involved inhuman gamete interaction will ultimately allow for both (i) the development of new malereproductive diagnostic capabilities and (ii) the design of improved and safer therapies aidingconception in childless couples suffering from male infertility.

[发布机构] Stellenbosch University