Role of the immune system in the microenvironment of malignant tumors of breast

[摘要] The recent advances in the understanding of the genetic and molecular mechanisms of breast cancer have demonstrated that immune system plays important events responsible for the development and progression of the tumor. The cells of the innate and adaptive immune system, as well as diverse soluble mediators, may establish a protective anti-tumor response or, on the contrary, to induce events of chronic inflammation that favor promotion and progression of disease. This duality occurs in the tumor microenvironment, which can regulate the carcinogenesis depending on the predominant immune cells. This revision summarizes the current knowledge of the relationship between immune system - breast cancer, emphasizing in the immune cells of the tumor microenvironment and its importance as biological markers of the clinical evolution of the disease.  

[学科分类] 生理学与病理学

[关键词] breast cancer;immune response;chronic inflammation;tumor microenviroment;tumor-infiltrating lymphocytes (TIL)