Behavior of the natural killer cells, dendritic cells and macrophages in pregnancy

[摘要] The implantation of a semiallogenic embryo in the womb is an immunological paradox and is one of the phenomena that open more questions in the field of immunology. While at one point it was considered that the maternal-fetal interface was an immunologically privileged site, now it is known that a fetus semiallogenic recognition by the immune system of the mother occurs. However, despite this immune recognition several mechanisms have been discovered that may explain why the mother does not reject the fetus antigenically different. These mechanisms include both fetal factors and local maternal factors, where the elements of innate and adaptive immune response are included. In this paper we refer to the important role of natural killer cells, dendritic cells and macrophages in pregnancy.

[学科分类] 生理学与病理学

[关键词] immunotolerance;pregnancy;maternal-fetal interfase;innate immune cells;fetal trophoblast