Adoptive cell immunotherapy with blood cord lymphocites in viral infections post hematopoietic transplant

[摘要] Viral reactivation predominantly occurs in the first 3 - 6 months after stem cell transplantation. The most clinically important are the herpes viruses; cytomegalovirus, Epstein-Barr virus and human herpes virus 6; the polyoma viruses BK and JC and adenovirus. Cellular adoptive immunotherapy is a treatment used to help immune system to fight against this kind of diseases. It is based on the extraction of specific T lymphocytes from an individual and its culture at the laboratory, to increase the number of T cells able to destroy viral targets, and these T cells are infused to the patient in order to help his immune system. In vitro experimental data suggest the high and perhaps unique potential of cord blood cells to generate biologically active products as therapeutic tools of this new type in order to facilitate graft, immunotherapy and regenerative medicine. A naive T cell phenotype derived from cord blood has been employed to reduce graft versus host disease after stem cell transplantation and as adoptive cellular immunotherapy with virus-specific cytotoxic T lymphocytes to prevent, in an effective way, this kind of viral infections.

[学科分类] 生理学与病理学