ALLIC-BFM 2002 protocol in the Institute of Hematology and Inmunology: ten years of experience

[摘要] Introduction:acute lymphoid leukemia (ALL) is the most common malignancy in childhood and it was the first disease treated with a common protocol in Cuba. Objective:to show therapeutic results achieved at the Instituto de Hematología e Inmunología, La Habana, with protocol ALL-IC BFM 2002 from 2002 to 2008.Methods and Patients: 125 children treated from January 2002 and December 2011 were included in the study. Patients were classified in prognostic groups according to age at diagnosis, initial leukocyte count, molecular rearrangement studies and response to therapy.Results: median follow up was 5,8 years; median of age was 5,2 years, and there were more boys than girls with a 1,5/1 ratio. Percentage of ALL of B-cell origin was 81,3 % and TEL-AML1 genetic rearrangement was the most common one with 24,1 %.There were a good response to prednisone prophase in 95,2 % and initial remission was obtained in 91,6 % of the patients and 4% died during the induction phase. Overall survival and event free survival for the whole group after seven years were 74,3 % and 68,9 %, respectively. In standard risk patients results were 84,2 % and 82 %. In Intermediate risk group were 71,8 % and 68,5 %; and in the high risk group were 25,4% for both curves. At the moment of the evaluation 75 % of the patients were in remission. Conclusions:percentages of overall survival and event free survival were similar to the ones obtained by other centers that use similar protocols elsewhere.

[学科分类] 生理学与病理学

[关键词] acute lymphoid leukemia;ALLIC-BFM protocol;event free survival;overall survival